Protein structure - Wikipedia, the free encyclopedia
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Proteins are an important class of biological macromolecules present in all biological organisms, made up of such elements as carbon, hydrogen, nitrogen, oxygen, and sulphur. All proteins are polymers...
en.wikipedia.org/wiki/Protein_structure
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Background: Many clinical diagnostic tests depend on the accurate detection and quantification of proteins and peptides and their functions. Alterations of protein structure, and the resulting consequences on dynamics, can affect the outcome of laboratory tests.
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www.clinchem.org/cgi/content/abstract/48/12/2105
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Protein Conformation and Dynamics in Protein-based Diagnostic Assays ... Standard immunometric diagnostics rely on binding events predicated on the target protein adopting a single conformation. However, in the case of infectious prions, PrPSc appears to adopt a variety of conformations (23)(26)(27),
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www.clinchem.org/cgi/content/full/48/12/2105
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Definition of protein conformation from the online medical dictionary hosted by mondofacto. ... online medical dictionary | definition of protein conformation...
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www.mondofacto.com/facts/dictionary?protein+conformatio...
www.mondofacto.com/facts/dictionary?protein+conformation
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B. What Determines Protein Conformation? ... This conformation is influenced by physical and chemical environmental conditions.; ... If a protein’s environment is altered, it may become denatured and lose its native conformation.
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home.minneapolis.edu/~albersmi/BIOL2200/Path_notes/ch5/...
home.minneapolis.edu/~albersmi/BIOL2200/Path_notes/ch5/ch5VIIb.htm
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C: UNDERSTANDING PROTEIN CONFORMATION ... describe the similarities between torsion angles and an energy vs torsion angle plot for the rotation of the C2-C3 torison angle with phi/psi angles of peptide bonds and the 2D plots off allowed conformations around a given amino acid in a protein (Ramachandran plot).
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employees.csbsju.edu/hjakubowski/classes/ch331/protstru...
employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html
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(a) A protein s conformation determines how it works. In almost every case, the function of a protein depends on its ability to recognize and bind to some other molecule.
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www.mansfield.ohio-state.edu/~sabedon/campbl05.htm
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In prion diseases, such as variant Creutzfeldt-Jakob disease normal cellular prion protein (PrPC), a largely -helical structure is converted to an abnormal conformational isoform (PrPSc) that shows an increase in -sheet content. ... Protein Conformation Significantly Influences Immune Responses to Prion Protein1...
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www.jimmunol.org/cgi/content/full/174/6/3256
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Protein Conformation Significantly Influences Immune Responses to Prion Protein1 ... Similarly, the recombinant form of PrPC (r -PrP) can be converted to a conformation dominated by -sheet (r -PrP) by reduction and mild acidification in vitro, a process that may mimic in vivo conversion following PrPC internalization...
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www.jimmunol.org/cgi/content/abstract/174/6/3256
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