The oxidation process by molybdenum-containing enzyme, xanthine oxidase, is theoretically studied with a model complex representing the reaction center and a typical benchmark substrate, formamide. Moreover, the product of the concerted mechanism is not consistent with the isotope experimental result. In addition to...
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pubs.acs.org/doi/abs/10.1021/ja068584d
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Xanthine oxidase - Wikipedia, the free encyclopedia
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Xanthine oxidase ( XO , a form of xanthine oxidoreductase that generates reactive oxygen species) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze th...
en.wikipedia.org/wiki/Xanthine_oxidase
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The inhibition of xanthine oxidase by its reaction product, uric acid, ... The ba sic catalytic mechanism of xanthine oxidase reactions can be ascribed to ...
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linkinghub.elsevier.com/retrieve/pii/0167483892903214
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The oxidative hydroxylation of xanthine to uric acid takes place at the ..... On the basis of these results, two quite different reaction mechanisms have ...
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www.pnas.org/content/101/21/7931.full
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Inhibition by uric acid of the xanthine : NAD' oxidoreductase reaction catalyzed by .... M. P. Coughldn and K. V. Rajagopalan: Kinetic Mechanism of Xanthine ...
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doi.wiley.com/10.1111/j.1432-1033.1980.tb04476.x
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Kinetic mechanism of chicken liver xanthine dehydrogenase. ... 1:1 for uric acid and 1:2 for NADH in the xanthine/NAD+ oxidoreductase reaction. ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC1148681/
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Calorimetric and Solubility Measurements on Uric Acid and Xanthine ... Anhydrous uric acid and its dihydrate are frequently found as constituents of renal calculi, whereas xanthine is only detected in less than 1% of all kidney stones.
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sol.cc.u-szeged.hu/~spec98/abstr/wang.html
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Xanthine dehydrogenase catalyzes the oxidation of hypoxanthine to xanthine and the further oxidation of xanthine to uric acid. The enzyme is the target of the anti-gout drug allopurinol and ... The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition.
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lib.bioinfo.pl/pmid:11092937
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Abstract Xanthine oxidase (XO) and dehydrogenase (XDH) are molybdenum enzymes that catalyze the conversion of hypoxanthine to xanthine and xanthine to uric acid. ... Research has indicated similar structure and mechanism, ... Kinetics for the E232A mutant show slower reaction rates for both the xanthine and hydroxyl-methylpurine (HMP).
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www.ohiolink.edu/etd/view.cgi?osu1089910515
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