In biology, senescence is the state or process of ageing. Cellular senescence is a phenomenon where isolated cells demonstrate a...
|
en.wikipedia.org/wiki/Ageing
|
|
An overview of current research on the biology of human aging and its importance to society. Aging, or senescence, is the major cause of suffering, disease, and death in Western civilization. Gerontology, also called biogerontology, is the science that studies the aging process to prevent age-related disease...
|
www.senescence.info/
www.senescence.info/
|
|
Basic definitions and concepts in the study of aging.
|
www.senescence.info/definitions.html
www.senescence.info/definitions.html
|
|
Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very...
|
www.sciencemag.org/cgi/content/abstract/311/5765/1257
|
|
; How is cellular senescence related to aging? Other evidence exists to suggest a relationship between cellular senescence and aging. For example, some of the senescent cells' functional losses appear to contribute to the aging process. For example, certain skin cells produce collagen during their younger,
|
websites.afar.org/site/PageServer?pagename=IA_b_sene_03...
websites.afar.org/site/PageServer?pagename=IA_b_sene_03_aging
|
|
Aging, life span, and senescence. Leonard Guarente*,; Gary Ruvkun†, and; Richard Amasino‡ Research in the field of aging recently has entered a new era.
|
www.pnas.org/content/95/19/11034.full
|
|
While there has been some question as to whether cellular senescence contributes to organismal aging, it is believed that senescence can lead to the reduction of the regenerative potential of the stem The contribution of SirT1 to senescence and aging in mammals is complex, and may involve non-chromatin substrates.
|
www.impactaging.com/papers/v1/n2/full/100023.html
www.impactaging.com/papers/v1/n2/full/100023.html
|
|
The most widely accepted overall theory of aging is currently the evolutionary senescence theory of aging. Much experimental evidence exists to support the basic premises of the evolutionary senescence theory of aging. For example, the theory predicts that delaying the age of reproduction should delay aging,
|
websites.afar.org/site/PageServer?pagename=IA_b_the_evo...
websites.afar.org/site/PageServer?pagename=IA_b_the_evol_senesce
|
|
IN the past, the debate over the relationship between cellular senescence and aging has been phrased in terms of whether this cell culture phenomenon is a model "for" aging.
|
biomed.gerontologyjournals.org/cgi/content/full/57/7/B2...
biomed.gerontologyjournals.org/cgi/content/full/57/7/B251
|
|
