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For both circadian rhythms and for sleep, flies are helping us to understand the genetic mechanisms that underlie these complex behaviors. Since 1971, discoveries in the fly have led the way to a number of significant discoveries, establishing a mechanistic framework that is now known to be conserved in the mammalian clock.
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jap.physiology.org/cgi/content/full/94/4/1660
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A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. ... Circadian Rhythm [physiology]
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www.medscape.com/medline/abstract/16251950
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This study examined sleep, fatigue, and circadian rhythms in women with breast cancer before the start of chemotherapy. PATIENTS AND METHODS: Eighty five women with Stages I-IIIA breast cancer who were scheduled to begin adjuvant or neoadjuvant anthracycline-based chemotherapy participated.
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www.medscape.com/medline/abstract/16010529
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How do circadian rhythms effect sleep? ... When travelers pass from one time zone to another, they suffer from disrupted circadian rhythms, an uncomfortable feeling known as jet lag. For instance, if you travel from California to New York, you "lose" 3 hours according to your body's clock.
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www.medicinenet.com/script/main/art.asp?articlekey=7973...
www.medicinenet.com/script/main/art.asp?articlekey=79735&page=5
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Circadian Learning Center: Understanding Your Circadian Rhythms - Self-guided Tutorials on Circadian Rhythms, the Biological Clock, Alertness,and Sleep...
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www.stanford.edu/~dement/circadian.html
www.stanford.edu/~dement/circadian.html
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Actigraphy, the use of a portable device that records movement over extended periods of time, and has been used extensively in the study of sleep and circadian rhythms, provides an acceptably accu ... Sleep / Sleep Disorders / Insomnia News...
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www.medicalnewstoday.com/articles/66873.php
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HUMAN SLEEP and circadian rhythms have evolved in adaptation to an environment characterized by a 24-h light-dark cycle and a gravitational force of 1 G. During spaceflight, both the exposure to the main synchronizer of the human circadian timing system, i.e., the light-dark cycle, as well as exposure to...
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ajpregu.physiology.org/cgi/content/full/281/5/R1647
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While sleep disturbance and circadian dysregulation are critical pathophysiological elements in bipolar disorder, many questions about the mechanisms that underpin the association remain.
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ajp.psychiatryonline.org/cgi/content/abstract/165/7/820
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