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SLURP-1 applications exhibited similar activity with all the ACh concentrations tested, except 10 µM. The dose–response curve indicates that SLURP-1 potentiates 7 nAChR homopentamers, since the EC50 was 175 µM ACh for the controls and dropped to 68 µM ACh after SLURP-1 treatment (Fig. 4B). The effects of SLURP...
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hmg.oxfordjournals.org/cgi/content/full/12/22/3017
hmg.oxfordjournals.org/cgi/content/full/12/22/3017
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The immortalized esophageal keratinocytes (Het-1A cells) exhibit low SLURP-1 and -2 mRNA levels that decrease further after treatment with NNK. ...
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www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2046...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2046218
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The Het-1A cells also contained the lowered SLURP-1 and -2 mRNA levels (p < 0.05) that decreased further after treatment of cells with NNK and NNN (Fig. ...
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linkinghub.elsevier.com/retrieve/pii/S0024320507000343
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SLURP-1 is also the causative gene for an autosomal recessive ...... in GH4C1 cells after treatment with 17β-estradiol, insulin and EGF, Arch. Histol. ...
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linkinghub.elsevier.com/retrieve/pii/S0168010209001448
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1C show that N-glycosidase treatment did not modify the migration of SLURP-1, indicating that SLURP-1 is not glycosylated. Example 3 ...
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www.patentstorm.us/patents/7135454/description.html
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Also disclosed are compositions and methods for the treatment or prevention ... Antibodies generated against SLURP-1 and related proteins are also included. ...
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www.patentstorm.us/patents/7135454.html
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Disclosed herein are compositions and methods for the treatment or prevention of neurological disorders. Also disclosed are compositions and methods for the treatment or prevention of skin pathologies. ... Antibodies generated against SLURP-1 and related proteins are also included.
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www.patentgenius.com/patent/7135454.html
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Unbound MEDLINE | A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia. Journal article. Search by keyword, journal, author or by EBM filters diagnosis, treatment, prognosis or etiology. ... Br J Dermatol 2003 Dec; 149(6):1108-15. ... Charfeddine C, Mokni M,
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www.unboundmedicine.com/medline/ebm/record/14674887/abs...
www.unboundmedicine.com/medline/ebm/record/14674887/abstract/A_novel_missense_mutation_in_the_gene_encoding_SLURP_1_in_patients_with_Mal_de_Meleda_from_northern_Tunisia_
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Chimienti et al (2003) demonstrated that SLURP-1 is secreted by N-terminal signal cleavage and acts as a modulator of the 7 nicotinic ACh receptor (nAChR). These authors examined ACh-elicited macroscopic current responses in control and SLURP-1-treated Xenopus oocytes expressing recombinant human 7 nAChR.
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www.nature.com/jid/journal/v125/n6/full/5603663a.html
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