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Soporific Effect of the Neurosteroid Pregnanolone in Relation to the Substance's Plasma Level: A Pilot Study; H. Schulza, M. Joberta, K.W. Geeb, D.W. Ashbrookc; aPAREXEL GmbH, Independent Pharmaceutical Research Organization, Berlin, Germany;
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content.karger.com/ProdukteDB/produkte.asp?Doi=119300
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It may be that the typical soporific effects observed after daytime oral doses of 0.3 mg melatonin reflect a pharmacological side effect of the hormone, rather than a mimicking of the normal physiological action.
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ajpendo.physiology.org/cgi/content/full/276/2/E249
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Wall Street Journal reporter Heather Won Tesoriero has covered the Vioxx trials since things got underway in Texas last summer. This week she’s at it again, down in the Big Easy for trial number five. She filed this report with the Law Blog fron New Orleans: If there was any [...] ... Virtual Stock Exchange...
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blogs.wsj.com/law/2006/02/08/merck-trial-5s-soporific-e...
blogs.wsj.com/law/2006/02/08/merck-trial-5s-soporific-effect/
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The soporific effect of the neuroactive steroid pregnanolone, a metabolite of progesterone, and its relationship with plasma concentrations was assessed in 18 young, healthy, male volunteers for 2 h after administration of a single dose of pregnanolone prepared in two different formulations.
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www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?...
www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?ID=19971781
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Discussion: The results of the study offer the first actigraphic observation supporting the use of a two-hour interval for the optimal soporific effect of exogenous melatonin.
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www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?...
www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?ID=19979631
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wonkette.com/147870/daily-briefing-part-i-alitos-sopori...
wonkette.com/147870/daily-briefing-part-i-alitos-soporific-effect
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Places I want to go (6) | Places I've been (17)
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www.43places.com/person/Soporificeffect
www.43places.com/person/Soporificeffect
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The effect is bizarre: 11 moving images of Mr. Starck's bearded face, each talking — sometimes even singing — simultaneously. With music created by Laurie Anderson rumbling in the background, the cumulative noise resembles that of a loud cocktail party and, after an hour or so, can become soporific.
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www.achehtimes.com/wordwealth/a-z/s/soporific.htm
www.achehtimes.com/wordwealth/a-z/s/soporific.htm
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TV overnights: Its soporific effect lasted right to the end with Channel 4 sleep-deprivation reality TV contest attracting fewer than two million viewers on Saturday night, writes Jason Deans. ... For from climaxing with a Big Brother-style audience boost, ... The audience for Britain's Best Sitcom actually peaked at 11.30pm,
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www.guardian.co.uk/media/2004/jan/12/overnights
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