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To clarify the differences in the epidemiological and clinical features between Guam ALS and sporadic ALS, the surveys were conducted in Guam for the periods from 1980 to 1989, in Rochester, MN, USA from 1952 to 1991 and in Hokkaido, Japan from 1980 to 1989. The crude incidence rate of Guam ALS was 7.5/100,000/year,
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www.medscape.com/medline/abstract/12795170
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"Our data suggest that there are no common genetic variants that exert an effect greater than an odds ratio of 4 in sporadic ALS," the researchers, with corresponding author Bryan J. Traynor, MD, from Johns Hopkins University in Baltimore and the National Institute of Mental Health, in Bethesda, Maryland, conclude.
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www.medscape.com/viewarticle/552952?rss
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Who you, a Guru? After you read these 50 ALS tips, you'll be one. But we're looking to recruit a Guru to blog, ... Q: Tell me more about Sporadic ALS? How common is it? ... Sporadic ALS is the most common form of ALS, especially in North America. It is found within 90 to 95 percent of all people diagnosed with ALS.
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als.lifetips.com/faq/113654/0/tell-me-more-about-sporad...
als.lifetips.com/faq/113654/0/tell-me-more-about-sporadic-als-how-common-is-it/index.html
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This work with familial ALS could lead to a greater understanding of sporadic ALS as well. Because familial ALS is virtually indistinguishable from sporadic ALS clinically, some researchers believe that familial ALS genes may also be involved in the manifestations of the more common sporadic form of ALS.
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www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis...
www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_amyotrophiclateralsclerosis.htm
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"The work shows there is no single gene out there which causes most of sporadic ALS, but we now have many leads to follow," says Bryan Traynor, M.D., of the National Institute of Mental Health (NIMH) at NIH and The Johns Hopkins University School of Medicine, who led the study in collaboration with researchers at the NIH...
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www.ninds.nih.gov/news_and_events/news_articles/news_ar...
www.ninds.nih.gov/news_and_events/news_articles/news_article_ALS_gene_variation.htm
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Blood samples from more than 220 ALS patients at the Methodist Neurological Institute were used in research that revealed significant changes in or around 10 specific genes in sporadic ALS, the mo ... Muscular Dystrophy / ALS News...
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www.medicalnewstoday.com/articles/78766.php
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A University of California, Irvine neurologist is part of a national group of scientists who have identified the active genes in sporadic amyotrophic lateral sclerosis (ALS), a discovery that prov ... Muscular Dystrophy / ALS News...
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www.medicalnewstoday.com/articles/78567.php
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A second study linking new genes to sporadic ALS was published this week in Nature Genetics. This multi-center study of 4,855 people with ALS and 14,953 controls, was led by ALS Association-funded investigators Roel Ophoff and Leonard van den Berg of the University Medical Center in Utrecht, The Netherlands.
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www.alsa.org/research/article.cfm?id=1507
www.alsa.org/research/article.cfm?id=1507
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Amyotrophic Lateral Sclerosis - Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the anterior horn cells of the spinal cord and the motor cranial nuclei that leads to progressive muscle weakness and atrophy. ... Sporadic ALS shares clinical features with familial ALS. However, no SOD1 mutations or...
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www.emedicine.com/neuro/topic14.htm
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