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It is more common for a sporadic disease to be a dominant genetic disease. The obvious reason is that a dominant disease requires only one random mutation, whereas two identically located mutations are required for recessive diseases.
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www.wrongdiagnosis.com/genetics/sporadic.htm
www.wrongdiagnosis.com/genetics/sporadic.htm
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What are the molecular bases of sporadic disease? Sporadic disease could represent a chromosomal abnormality or a recessive trait, or be due to de novo dominant mutations. To what extent are new mutations (that is, de novo events) responsible for sporadic traits?
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www.nature.com/uidfinder/10.1038/ng2084
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Objective: To define the incidence, demographics, clinical features, and risk factors for sporadic meningococcal disease in adults (≥ 18 years) residing in metropolitan Atlanta.
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www.annals.org/cgi/content/full/123/12/937
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Whereas the majority of cases of CJD (about 85%) occur as sporadic disease, a smaller proportion of patients (5-15%) develop CJD because of inherited mutations of the prion protein gene. These inherited forms include Gerstmann-Straussler-Scheinker syndrome and fatal familial insomnia...
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www.cdc.gov/ncidod/dvrd/cjd/
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Hutchinson encyclopedia article about sporadic disease. sporadic disease. Information about sporadic disease in the Hutchinson encyclopedia. ... In humans, infections caused by micro-organisms (pathogens) are the commonest cause of disease. According to a 1990s World Health Report prepared by the World Health Organization,
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encyclopedia.farlex.com/sporadic+disease
encyclopedia.farlex.com/sporadic+disease
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Example 3: Meningococcal Disease ... The following are examples of Sporadic Disease : ... ; The following are not examples of Sporadic Disease , but are often confusing:
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www.vetmed.wisc.edu/education/courses/epi/concepts/Spor...
www.vetmed.wisc.edu/education/courses/epi/concepts/Sporadic%20Disease/tabs/examples.html
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Clin Infect Dis. 2004; 38 Suppl 3:S115-20 (ISSN: 1537-6591) ... Allos BM; Moore MR; Griffin PM; Tauxe RV; Vanderbilt University School of Medicine, Nashville, Tennessee, USA ... Ob/Gyn & Women's Health...
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www.medscape.com/medline/abstract/15095179
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The findings are of obvious interest to the study of sporadic prion disease, but there are also broader ramifications: If PrPC is being differentially glycosylated with age, might other proteins passing through the secretory pathway also be affected?
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ouroboros.wordpress.com/2006/12/14/sweet-madness-sporad...
ouroboros.wordpress.com/2006/12/14/sweet-madness-sporadic-prion-disease-and-age-related-changes-in-protein-glycosylation/
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Background Mutations in leucine-rich repeat kinase 2 gene (LRRK2), particularly the G2019S mutation in exon 41, have been detected in familial and sporadic Parkinson disease (PD) cases.
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archneur.ama-assn.org/cgi/content/full/64/3/425
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