Amide - Wikipedia, the free encyclopedia
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In chemistry, an amide is usually an organic compound that contains the functional group consisting of an acyl group (R-C=O) linked to a nitrogen atom (N). The term refers both to a class of compoun...
en.wikipedia.org/wiki/Amide
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Peptide bond - Wikipedia, the free encyclopedia
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A peptide bond ( amide bond ) is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amine group of the other molecule, thereby releasing a molecul...
en.wikipedia.org/wiki/Peptide_bond
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Hi-Res PDF[6218 KB] ... Helmut Sigel, R. Bruce Martin ... Note: In lieu of an abstract, this is the article's first page.
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pubs.acs.org/doi/abs/10.1021/cr00050a003
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Christopher S. J. Walpole, Roger Wrigglesworth, Stuart Bevan, Elizabeth A. Campbell, Andy Dray, Iain F. James, Kay J. Masdin, Martin N. Perkins, Janet Winter ... Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region"Journal of Medicinal Chemistry...
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pubs.acs.org/doi/abs/10.1021/jm00068a015
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Peptide isosteres are important tools for the understanding of peptide function and for the development of drugs. ... (E)-Alkene peptide isosteres are particularly useful due to their close geometric match of the amide bond structure. We developed a method for the generation of a small library of (E)-alkene peptide isosteres...
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etd.library.pitt.edu/ETD/available/etd-07192008-221135/
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BioInfoBank Library :: Resonance structures of the amide bond: the advantages of planarity. Reaction mechanism of the acidic hydrolysis of highly twisted amides: rate acceleration caused by the twist of the amide bond. ... The amide bond may be considered as one of the most important chemical building blocks,
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lib.bioinfo.pl/pmid:16807968
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Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. ... PubChem Structure Search...
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www.ncbi.nlm.nih.gov/pubmed/17936629
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The incorporation of a reduced amide bond, psi(CH(2)NH), into peptide results in an increase in the net positive charge and the perturbation of alpha-helical structure. ... By using this characteristic of the reduced amide bond, we designed and synthesized novel pseudopeptides containing ... Structure-Activity Relationship...
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www.medscape.com/medline/abstract/11104671
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The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. ... The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring as an isosteric replacement for the P1'--P2' amide bond.
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www.aegis.com/aidsline/1995/jan/M9510448.html
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