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These particular residues seem to be located centrally in the binding site as indicated by a structure model analysis. The importance of several of these conserved residues was supported by their presence in a mouse monoclonal antibody with a known structure and the same epitope specificity.
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www.medscape.com/medline/abstract/11287680
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The location and description of epitopes on proteins describe the basis of immunological specificity. ... The 2.8-A structure of the phosphocarrier protein, HPr from Escherichia coli, complexed to the Fab fragment of the monoclonal antibody, Jel42, has been determined.
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www.medscape.com/medline/abstract/7684366
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Antibody - Wikipedia, the free encyclopedia
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Antibodies (also known as immunoglobulins , abbreviated Ig ) are gamma globulin proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identi...
en.wikipedia.org/wiki/Antibody
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Structure of an Antibody; It is important to learn about the structure of an antibody and why they are such important molecules in immunocytochemistry ... What Is It? ... Antibody Staining?
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www.wellesley.edu/Biology/Concepts/Html/antibody.html
www.wellesley.edu/Biology/Concepts/Html/antibody.html
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Antibody Development ... Antibody Overview ... Antibody Evolution...
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www.medarex.com/Development/Structure.htm
www.medarex.com/Development/Structure.htm
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Brief Introduction to Antibody Structure ... The basic structure of all antibody or immunoglobulin (Ig) molecules consists of 4 protein chains shaped like a capital letter "Y" and linked by disulphide bonds. There are two pairs of chains in the molecule: heavy and light.
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www.cryst.bbk.ac.uk/~ubcg07s/Intro.html
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Visit the page of information and links to accompany my book chapter Protein Sequence and Structure Analysis of Antibody Variable Domains. In: Antibody Engineering Lab Manual (Ed.: Duebel, S. and Kontermann, R., Springer-Verlag, Heidelberg).
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The structure of the combining site of the DNP binding IgA mouse myeloma protein MOPC 315 has been determined by a combination of high resolution nuclear magnetic resonance, electron spin resonance, model building and chemical modifications.
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www.nature.com/nature/journal/v266/n5597/abs/266031a0.h...
www.nature.com/nature/journal/v266/n5597/abs/266031a0.html
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Abcam - Antibodies & Reagents, find any antibody. ... An antibody is defined as an immunoglobulin (glycoprotein) capable of specific combination with the antigen that caused its production in a susceptible animal. They are produced in response to the ... Resources > Abcam's antibody guide > Antibody structure and isotypes...
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www.abcam.com/index.html?pageconfig=resource&rid=11258&...
www.abcam.com/index.html?pageconfig=resource&rid=11258&pid=11287
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