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Synaptic plasticity - Wikipedia, the free encyclopedia
In neuroscience, synaptic plasticity is the ability of the connection, or synapse, between two neurons to change in strength. There are several underlying mechanisms that cooperate to achieve synapt...
en.wikipedia.org/wiki/Synaptic_plasticity |
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Neuroplasticity - Wikipedia, the free encyclopedia
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These deficits are accompanied by minimal or no loss of presynaptic or postsynaptic elementary structural elements in the hippocampus, suggesting that impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in Alzheimer's patients.
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Synapsins are abundant synaptic-vesicle phosphoproteins that are known to regulate neurotransmitter release but whose precise function has been difficult to pinpoint. Here, we use knockout mice to analyze the role of synapsins 1 and 2 in the calyx of Held synapse, allowing precise measurements of neurotransmitter release.
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Consistent with the notion that this cyclic guanosine 3',5'monophosphate-mediated inhibitory pathway is recruited by some patterns of synaptic activity, blocking cyclic guanosine 3',5'monophosphate production strongly facilitated the induction of long-term potentiation by long trains of theta-frequency synaptic stimulation.
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Synaptic plasticity was first proposed as a mechanism for learning and memory on the basis of theoretical analysis (Hebb, 1949). The plasticity rule proposed by Hebb postulates that when one neuron drives the activity of another neuron, the connection between these neurons is potentiated.
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