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long stretches at the ends of the chromosome, the telomeres. ... Telomeres are crucial to the life of the cell. They keep the ends of the various chromosomes in the cell from accidentally becoming attached to each other.
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users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Telom...
users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Telomeres.html
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Telomere - Wikipedia, the free encyclopedia
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A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from destruction. Its name is derived from the Greek nouns telos ( τἐλος ) "end" and m...
en.wikipedia.org/wiki/Telomere
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Thus, telomeres shorten each time a cell divides, until they cannot protect chromosomes and the cell dies. But in cancer, it is believed that telomerase is activated and intervenes to keep telomeres from shortening, allowing for unlimited cell division.
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www.medicalnewstoday.com/articles/23040.php
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A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at ... At the end of these chromosomes are telomeres, zones of repeated chains of DNA that are often compared to the plastic tips...
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www.medicalnewstoday.com/articles/84714.php
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Telomeres and cancer; The obvious question is this: If senescence is caused or exacerbated by the erosion of telomeres that accompanies cell division, and if every cell is capable of producing an enzyme that can halt or reverse that process, why is that gene turned off in most tissues for most of life?
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www.telomere.net/
www.telomere.net/
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Telomeres are a DNA sequence that appears at the end of each chromosome. When cells divide, the telomeres get shorter. Eventually the telomeres are so short the cell can no longer divide. This triggers cell aging and death of the cell. ... The process does not copy all of the DNA information - the telomeres are not copied.
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longevity.about.com/od/researchandmedicine/p/telomeres....
longevity.about.com/od/researchandmedicine/p/telomeres.htm
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Alternative Lengthening of Telomeres ... Examination of the chromosome ends in these cells revealed that they had telomeres of varying lengths, ranging from very short to very long. This indicated that the cells did not seem to sense or respond to telomere length.
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www.medscape.com/viewarticle/447832_4
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We demonstrate here that G-tails of 12-14 bases are present outside of S phase on normal yeast telomeres. Furthermore, the Mre11p protein is essential for the proper establishment of this constitutive end-structure.
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www.medscape.com/medline/abstract/15198981
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Telomeres have been compared with the plastic tips on shoelaces because they prevent chromosome ends from fraying and sticking to each other, which would scramble an organism's genetic information to cause cancer, other diseases or death.
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learn.genetics.utah.edu/content/begin/traits/telomeres/
learn.genetics.utah.edu/content/begin/traits/telomeres/
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[tĕĺə-mîŕ, tḗlə-]
