That the effects of the TnC mutants were most prevalent at subsaturating Ca2+ may be of physiological consequence considering cardiac muscle functions primarily at subsaturating Ca2+ levels, and many of the cardiac disease-associated Tn mutations alter the Ca2+ sensitivity of force development (for review8).
cardiovascres.oxfordjournals.org/cgi/content/full/77/4/... cardiovascres.oxfordjournals.org/cgi/content/full/77/4/619
Muscle - Wikipedia, the free encyclopedia
Source
Muscle (from Latin musculus , diminutive of mus "mouse") is the contractile tissue of the body and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile f...
en.wikipedia.org/wiki/Muscle
Myofilaments can be either thick filaments (comprised of myosin) or thin filaments (comprised primarily of actin). The characteristic 'striations' of skeletal and cardiac muscle are readily observable by light microscopy as alternating light and dark bands on longitudinal sections.
people.eku.edu/ritchisong/301notes3.htm
CARDIAC MUSCLE CONTRACTION is initiated by Ca2+ binding to troponin C (TnC), which triggers conformational changes on the thin filament, ... Effect of Pi on force generated in unextracted trabeculae. It has been shown that in the presence of added Pi force is depressed in cardiac muscle preparations (2, 16, 20).
ajpheart.physiology.org/cgi/content/full/293/4/H2580 ajpheart.physiology.org/cgi/content/full/293/4/H2580
Also the model output is the isometric contraction force, not the Ca2+ transient, as in previous models, to allow for a ... Hence, the simulation results suggest that negative feedback on sarcolemmal influx plays a critical role in producing the large degree of postextrasystolic potentiation observed in the cardiac muscle.
ajpheart.physiology.org/cgi/content/full/278/3/H913 ajpheart.physiology.org/cgi/content/full/278/3/H913
56). Interestingly, HSP27 is a known regulator of actin polymerization (57), suggesting that actin rearrangement is an important event in the mechanism of force maintenance during smooth muscle contraction.
www.ebmonline.org/cgi/content/full/230/11/829
Cardiac muscle contraction depends on the tightly regulated interactions of thin and thick filament proteins of the contractile apparatus. ... Dysfunctional properties observed with the FHC mutants include altered Ca2+ sensitivity, changes in ATPase activity, changes in the force and velocity of contraction,
jap.physiology.org/cgi/content/full/90/3/1125
Muscle fiber force was set equal to the product of stiffness and elastic distortion of stiffness elements, i.e., ... Despite an effort in the 1960s and 70s to build a quantitative bridge between whole-heart function and muscle-contraction indices (6), ... Time variation in on(t) and off(t) accrues primarily from a coefficient,
jap.physiology.org/cgi/content/full/104/4/958
such channels are primarily responsible for terminating an action potential and ending the contraction and refractory period of cardiac muscle cells while initiating repolarization; ... In the same figure, the green curve depicts the force of contraction during the same time period (tension on the Y axis to the right).
www.apsu.edu/thompsonj/Anatomy%20&%20Physiology/2020/20... www.apsu.edu/thompsonj/Anatomy%20&%20Physiology/2020/2020%20Exam%20Reviews/Exam%201/CH18%20Physiology%20of%20Contraction.htm
Superoxide anion was detected primarily to help identify conditions in which cardiac muscle superoxide production or scavenging was altered by the treatments used. ... Figure 6. Effects of a 15-minute hypoxia and reoxygenation treatment on cardiac contraction in the absence (control) and presence of probes for NO, O2-,
circres.ahajournals.org/cgi/content/full/82/8/891