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We appreciate Dr. Raggi's comments on the potential for normally therapeutic theophylline levels to produce significant cardiac disturbances. This risk has been reported by many investigators.
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www.annals.org/cgi/content/full/120/10/891-a
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On the other hand, theophylline is generally metabolized more rapidly in smokers (both tobacco and marijuana) and higher dosages may be required. High blood theophylline levels can lead to symptoms of toxicity (see below).
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www.medicinenet.com/theophylline/article.htm
www.medicinenet.com/theophylline/article.htm
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OBJECTIVES: To assay theophylline blood levels in a sample of Sri Lankan chronic asthmatics taking oral theophylline, and to evaluate a simple and cost effective ultraviolet spectrophotometric assay for theophylline levels in blood. ... DESIGN AND METHODS: A cross-sectional study of theophylline blood levels.
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www.medscape.com/medline/abstract/12140878
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Plasma steady-state concentrations of theophylline were measured by the standard TDx assay and a novel patient-side immunoassay system with a single-use cartridge (Biotrack 516) in 100 samples from 93 patients.
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www.medscape.com/medline/abstract/8249055
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Manuals, Hints, Guidelines, Articles and Help ... Therefore, the best way to monitor that the asthmatic is receiving the optimal amount of theophylline is to take a blood level concentration.
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stason.org/TULARC/health/asthma-allergy/2-4-1-Why-do-I-...
stason.org/TULARC/health/asthma-allergy/2-4-1-Why-do-I-need-a-blood-test-when-taking-theophylline.html
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Theophylline Blood Levels as a Guide to Intravenous Therapy in Children. James Fox, MD; Patricia Hicks, MD; Bernard R. Feldman, MD; William J. Davis, MD; ...
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archpedi.ama-assn.org/cgi/content/abstract/136/10/928
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Obtain serum theophylline levels every 2-4 hours until the level falls. ... By increasing the action of GABA, a major inhibitory neurotransmitter in the brain, may depress all levels of CNS, including limbic and reticular formation. Monitoring blood pressure after administering dose is important.
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www.emedicine.com/emerg/topic577.htm
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By noting blood theophylline levels in either blood serum or blood plasma the physician can determine, firstly, whether the patient under examination is following the prescribed dosage regimen and, secondly, whether this regimen is achieving the necessary blood levels for the desired therapeutic effect.
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www.freepatentsonline.com/4325908.html
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theophylline blood levels were determined. (luring repeated oral ad- ministration ... on blood level. Figure 1 contains blood levels of theophylline ...
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jpet.aspetjournals.org/content/100/3/309.full.pdf
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