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Tight junctions seal adjacent epithelial cells in a narrow band just beneath their apical surface. ... Tight junctions perform two vital functions: ... As long as the sheet of cells is intact, there is no stimulation of its receptors by heregulin thanks to the seal provided by tight junctions.
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users.rcn.com/jkimball.ma.ultranet/BiologyPages/J/Junct...
users.rcn.com/jkimball.ma.ultranet/BiologyPages/J/Junctions.html
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Tight junctions glue individual cells together within an epithelium, and in order to cross this sheet, molecules and ions must pass either through the epithelial cells (transcellular route) or between the cells and thus through the junctions (paracellular route).
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arbl.cvmbs.colostate.edu/hbooks/cmb/cells/pmemb/junctio...
arbl.cvmbs.colostate.edu/hbooks/cmb/cells/pmemb/junctions_t.html
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Cell junctions can be divided into two types: those that link cells together, also called intercellular junctions (tight, gap, adherens, and desmosomal junctions), and those that link cells to the extracellular matrix (focal contacts/adhesion plaques and hemidesmosomes).
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www.biologyreference.com/Ce-Co/Cell-Junctions.html
www.biologyreference.com/Ce-Co/Cell-Junctions.html
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b) Tight junctions: seal the space between two cells. They prevent the flow of molecules and ions through the EC space. Example: keep digestive juices, urine etc. in the their place.
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www.sjsu.edu/depts/Biology/facultystaff/soto/Celljuncti...
www.sjsu.edu/depts/Biology/facultystaff/soto/Celljunctions.html
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As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field.
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www.crcpress.com/us/product.asp?sku=2383&dept%5Fid=1
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Automatic download; [Begin manual download] ... Downloading the PDF version of:; Reproduction Tarulli et al. 135 (6): 867. (554K) ... This file is in Adobe Acrobat (PDF) format. If you have not installed and configured the Adobe Acrobat Reader on your system, see Help with Printing for instructions.
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www.reproduction-online.org/cgi/reprint/135/6/867
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We then assessed the localisation of the other key tight junction proteins in this hamster model. Low-level claudin-3 reactivity was observed in the interstitium of immature (d5) hamsters that lack tight junctions (Fig.
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www.reproduction-online.org/cgi/content/full/135/6/867
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Moreover, freeze-fracture studies of this region reveal simple linear ridges on fracture face P and grooves on fracture face E, which are similar to the less complex vertebrate tight junctions. The luminal clefts, which permit free inward diffusion of tracers, present no tight junctions, but do have septate junctions.
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www.sciencemag.org/cgi/content/abstract/204/4388/91
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