Gentlesk, Philip J.; Markwood, Thor T.; Atwood, J. Edwin.
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chestjournal.chestpubs.org/content/125/1/297.full
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Although several large-scale studies have established the prognostic value of the chronotropic response during exercise, the underlying mechanisms are not very clear. Chronotropic incompetence is generally believed to reflect an underlying autonomic nervous system imbalance.
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eurheartj.oxfordjournals.org/cgi/content/full/27/8/897
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Although previous groups have reported that an impaired HR response to exercise, or chronotropic incompetence, is an independent predictor of risk (2–6), this very well done observational study represents the first attempt to show its prognostic value over and above detailed findings of myocardial perfusion scintigraphy.
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content.onlinejacc.org/cgi/content/full/44/2/431
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Limited myocardial contractile reserve and chronotropic incompetence in patients with chronic Chagas’ disease ... Thus, dobutamine stimulation unmasks a chronotropic incompetence and a blunted myocardial contractile response in chagasic patients, even in those with no overt manifestation of heart disease...
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content.onlinejacc.org/cgi/content/abstract/33/2/522
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Effects Of Chronotropic Incompetence and Beta-Blocker Use on the Exercise Treadmill Test in Men ... The purpose of this study was to examine the effect of ß-blockers and chronotropic incompetence on the diagnostic accuracy of the exercise test.
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www.medscape.com/viewarticle/409254
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The Medscape Journal ... Allergy & Clinical Immunology ... Diabetes & Endocrinology...
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www.medscape.com/medline/abstract/12111660
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Conclusions An attenuated heart rate response to exercise, a manifestation of chronotropic incompetence, is predictive of increased mortality and coronary heart disease incidence.
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circ.ahajournals.org/cgi/content/full/93/8/1520
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Aims We prospectively evaluated results from cardiopulmonary exercise testing for chronotropic incompetence (CI) in a cohort of 292 pacemaker patients. In addition, we evaluated comorbidity and antiarrhythmic patient data as indicators of CI.
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europace.oxfordjournals.org/cgi/content/abstract/8/1/70
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Chronotropic incompetence--Part II: Clinical implications. ... The definition of chronotropic incompetence as inadequate chronotropic response to metabolic demand is, in theory, quite satisfactory. However, the method used in clinical practice for determination of chronotropic incompetence is far from established.
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www.ncbi.nlm.nih.gov/pubmed/8790957
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