cb140206.qxd (PDF File)
The subtitle of this article -- The Same and Not the Same -- is taken from a book of the same title by Roald Hoffmann, who presents the concept of molecular mimicry in chemical structures, ... The rhodopsin structure seems to provide a satisfactory template for other Family A GPCRs, as demonstrated in a 194 Cell...
www.rockefeller.edu/labheads/sakmar/articles/Sakmar_Cur... www.rockefeller.edu/labheads/sakmar/articles/Sakmar_Curr_Opin_Cell_Biol_2002.pdf
To read this article in full you may need to log in, make a payment or gain access through a site license (see right). ... Nature Structural & Molecular Biology 7, 710 (1 September 2000) | doi:10.1038/7892 ... I want to purchase this article...
www.nature.com/nsmb/journal/v7/n9/full/nsb0900_710.html
Nature - the world's best science and medicine on your desktop ... Nature Chemical Biology 2, 395 - 396 (2006) ... Figure 1 - Molecular representation of a GPCR based on the X-ray crystal structure of rhodopsin (ref. 13).
www.nature.com/nchembio/journal/v2/n8/fig_tab/nchembio0... www.nature.com/nchembio/journal/v2/n8/fig_tab/nchembio0806-395_F1.html
The retinal binding site is another area where the rhodopsin structure might prove useful in modeling other GPCRs. The hydrophobic chromophore is similar to the ligands bound by many GPCRs, and evidence is available to support the idea that the retinal site is representative of the ligand binding sites in those proteins.
www.ks.uiuc.edu/Services/Class/BIOPHYS490M/papers/Rh-st... www.ks.uiuc.edu/Services/Class/BIOPHYS490M/papers/Rh-structure-rev.pdf
We determined the structure of rhodopsin from diffraction data extending to 2.8 angstroms resolution. The highly organized structure in the extracellular region, including a conserved disulfide bridge, forms a basis for the arrangement of the seven-helix transmembrane motif.
www.sciencemag.org/cgi/content/abstract/289/5480/739
We determined the structure of rhodopsin from diffraction data extending to 2.8 angstroms resolution. ... Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data. N. Nagamine and Y. Sakakibara (2007); Bioinformatics 23, 2004-2012 ; | Abstract » | Full Text » | PDF »...
www.sciencemag.org/cgi/content/abstract/sci;289/5480/73... www.sciencemag.org/cgi/content/abstract/sci;289/5480/739?ck=nck
The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopyThe chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy...
pubs.acs.org/cgi-bin/jtext?bichaw/40/i26/abs/bi0155091
The aim of the present work is to apply this approach to construct and refine a 3D model of rhodopsin as a test case. ... After refinement the model of bacteriorhodopsin was compared with the experimental structure refined at 3.5 Å resolution. ... Accounts of Chemical Research...
pubs.acs.org/cgi-bin/abstract.cgi/jpcbfk/1999/103/i13/a... pubs.acs.org/cgi-bin/abstract.cgi/jpcbfk/1999/103/i13/abs/jp9820471.html
A Wisdom Archive on chemical structure ... RNA, RNA - History, RNA - Chemical structure, RNA - Comparison with DNA, RNA - Synthesis, RNA - Biological roles, RNA - Messenger RNA mRNA, RNA - Transfer RNA tRNA, RNA - Non-coding RNA or RNA genes, ... For example, the 11-cis-retinal isomer is the chromophore of rhodopsin, the v ...
www.experiencefestival.com/chemical_structure/page/2 www.experiencefestival.com/chemical_structure/page/2
Statistical prediction of protein–chemical interactions based on chemical structure and mass spectrometry data ... For a protein–chemical compound pair, the protein is represented by its amino acid sequence and the compound is denoted by either its mass spectrum or its chemical structure. The combination of a feature...
bioinformatics.oxfordjournals.org/cgi/content/full/23/1... bioinformatics.oxfordjournals.org/cgi/content/full/23/15/2004