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Mechanism of odorant adaptation in the olfactory receptor cell. ... Olfactory adaptation. The nose leads the eye. ... Mechanism of odorant adaptation in the olfactory receptor cell.Mechanism of odorant adaptation in the olfactory receptor cell.
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www.ncbi.nlm.nih.gov/pubmed/9034189
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This olfactory adaptation is odorant selective; animals can adapt independently to different odorants sensed by a single pair of olfactory neurons, the AWC neurons. The mechanism of olfactory adaptation is genetically complex, with different genes required for adaptation to different odorants.
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www.ncbi.nlm.nih.gov/pubmed/7718242
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Olfactory neurons adapt to prolonged odor exposure through calcium-calmodulin inhibition of cyclic nucleotide-gated channels. A study in this issue reveals a new mechanism for olfactory adaptation under native conditions, via unexpected binding sites.
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www.nature.com/doifinder/10.1038/nn0704-689
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Here we investigate the nature of the adaptational mechanism in intact olfactory cells by using a combination of odorant stimulation and caged cAMP photolysis15 which produces current responses that bypass the early stages of signal transduction (involving the receptor, G protein and adenylyl cyclase).
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www.nature.com/nature/journal/v385/n6618/abs/385725a0.h...
www.nature.com/nature/journal/v385/n6618/abs/385725a0.html
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The findings offer a mechanism by which a single, brief odor stimulus can be translated into long-lasting intracellular changes that could play an important role in the perceptual adaptation to odors, and explain the long-standing puzzle that the olfactory CNG channels can be gated by both cAMP and cGMP.25...
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www.leffingwell.com/olfact3.htm
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The receptor cells, called olfactory receptor cells, for the sense of smell are located in the olfactory epithelium lining the roof and sides of the nose. These cells are actually the neurons of the olfactory nerve.
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sciences.aum.edu/bi/bi2110/cadams/earnotes.htm
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Psychophysical analysis shows that olfactory adaptation results in elevations in odor thresholds and in reduced responsiveness to suprathreshold stimulation. Further, ... A Peripheral Mechanism for Behavioral Adaptation to Specific "Bitter" Taste Stimuli in an Insect; J. Neurosci., May 15, 2001; 21(10): 3688 - 3696.
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chemse.oxfordjournals.org/cgi/content/abstract/25/4/487
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It seems likely that even with odorants with different modalities adaptation occurs completely depending on the amount of current flow. The data will also provide evidence showing that olfactory response generation and adaptation are regulated by a uniform mechanism for a wide variety of odorants.
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jgp.rupress.org/cgi/content/abstract/122/3/255
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In an elegant set of experiments, these authors have ruled out a suspected mechanism of fast olfactory adaptation and have, by default, provided further evidence for another mechanism in the process.
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jgp.rupress.org/cgi/content/full/128/2/149
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