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A rapid method for the production of radioiodinated autologous fibrinogen (RAF) is given. The method is complete within 1 hr, can be conveniently handled in kit form, produces fibrinogen that is 85–90% clottable, and eliminates the risk of serum hepatitis transmission.
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jnm.snmjournals.org/cgi/content/abstract/15/11/974
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This is usually due to a rare inherited abnormality in the gene that produces fibrinogen, which leads to the production of an abnormal fibrinogen protein (dysfibrinogenemia). If clinical findings suggest a fibrinogen problem, other specialized tests may be done to further evaluate fibrinogen function.
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www.labtestsonline.org/understanding/analytes/fibrinoge...
www.labtestsonline.org/understanding/analytes/fibrinogen/test.html
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These substances activate proteins called clotting factors, such as fibrinogen. Until activated, clotting factors are dissolved in the blood. When fibrinogen is activated, it is converted to fibrin, which consists of long strands. ... Sometimes the bone marrow produces too many platelets, making blood more likely to clot.
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www.merck.com/pubs/mmanual_ha/sec3/ch49/ch49d.html
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To define better the role of the fibrinogen receptor in platelet physiology and to characterize it biochemically, a murine monoclonal antibody that completely blocks the binding of fibrinogen to the platelet surface was produced by the hybridoma technique with the aid of a functional screening assay.
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www.jci.org/articles/view/110973
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It may be that an increased amount of circulating fibrinogen produces an increased propensity for thrombosis7 or directly contributes to the development of the atherosclerotic lesion.8 There are also indications that increased plasma fibrinogen levels reflect the inflammatory condition of the vascular wall.
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atvb.ahajournals.org/cgi/content/full/15/7/856
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A comparison of the fibrinogen receptor distribution on adherent platelets using both soluble fibrinogen and fibrinogen immobilized on gold beads. ... The polymerization of fibrinogen Dusart (A alpha 554 Arg --> Cys) after removal of carboxy terminal regions of the A alpha-chains.
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www.textmed.com/chemical/fibrinogen-relation.htm
www.textmed.com/chemical/fibrinogen-relation.htm
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We have previously shown functional differences in fibrinogen from hyperhomocysteinemic rabbits compared to that in control rabbits. This acquired dysfibrinogenemia is characterized by fibrin clots that are composed of abnormally thin, tightly packed fibers with increased resistance to fibrinolysis. ... Publication Date (Web):
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pubs.acs.org/doi/abs/10.1021/bi052076j
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Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot. Dowd AJ, McGonigle S, Dalton JP. ...
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www.ncbi.nlm.nih.gov/pubmed/7556157
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A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC1129188/
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