Swallowing deficits short term vs long term Large tablets vs small tablets, shape and coating or capsules Lack of insight Timing of the dose Resistive to certain carers No longer want active treatment Patients resistive to care Research Aged Care We know anecdotally that crushing or altering of medication is common...
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www.mndgp.org.au/programs/documents_links/Aged%20Care/t...
www.mndgp.org.au/programs/documents_links/Aged%20Care/to%20crush%20or%20not%20to%20crush.pdf
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Crushed tablets Lists of tablets which should not be crushed have been published.22,23; ... Enteric-coated tablets should not be crushed, as the purpose of enteric-coating is to prevent drug dissolution in the stomach and to promote absorption in the small intestine (eg, mesalazine) or to protect the stomach from damage...
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www.pharmj.com/Hospital/Editorial/200006/features/manag...
www.pharmj.com/Hospital/Editorial/200006/features/managingdrugtherapy.html
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OBJECTIVE: To investigate whether crushed or dissolved tablets of the oral direct thrombin inhibitor ximelagatran are bioequivalent to whole tablet administration. ... The time to C(max) (t(max)) was 2.2h for the whole tablet and approximately 0.5 h earlier when the tablet was crushed or dissolved (1.7-1.8 h), due to a...
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www.medscape.com/medline/abstract/15025841
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Tegaserod from crushed tablets was stable in tap water for up to three days at either 20-25 °C or 5 °C (Table 1). The completeness-of-dose study indicated that patients who take crushed tegaserod tablets in water receive the complete dose of the medication;
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www.medscape.com/viewarticle/479517_3
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Single 800-mg telithromycin doses (2 x 400-mg tablets) were administered as crushed tablets mixed in 240 mL nutritional supplement drink followed by 120 mL water or as whole tablets swallowed with 240 mL water. Plasma telithromycin concentrations were measured by liquid chromatography/mass spectrometry;
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jcp.sagepub.com/cgi/content/abstract/45/9/1025
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Vet > Phenylbute Tablets 200 mg ... This page contains information on Phenylbute Tablets 200 mg for veterinary use. The information provided typically includes the following: ... 3. In many cases, tablets may be crushed and given with feed.
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www.drugs.com/vet/phenylbute-tablets-200-mg.html
www.drugs.com/vet/phenylbute-tablets-200-mg.html
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899 children aged 12 years or younger were randomly assigned to either dispersible (n=447) or crushed tablets (n=452). More than 85% of patients in each treatment group completed the study.
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www.thelancet.com/journals/lancet/article/PIIS0140-6736...
www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61492-0
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It was compared with the crushed commercial tablets of the same combination, as currently used, in a randomised trial of 899 children in several endemic countries in Africa. Efficacy and safety profiles of the two formulations were similar.
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www.thelancet.com/journals/lancet/article/PIIS0140-6736...
www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61492-0/fulltext
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MR should not be crushed. Non-MR tablets can be dispersed in water. ... Tablets can be crushed and dispersed in water. The crushed tablets have a bitter taste. ... For NG tubes use the liquid as the crushed tablets form a thick sludge which may block NGs.
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www.formulary.cht.nhs.uk/Guidelines/MMC/062b_MedEnt_Ind...
www.formulary.cht.nhs.uk/Guidelines/MMC/062b_MedEnt_IndivDrugs.htm
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