Liver repopulation assays in intact animals showed markedly decreased replication capacity in polyploid hepatocytes. Recapitulation of polyploidy in cultured hepatocytes established that mitogenic stimulation in the presence of oxidative DNA injury was capable of inducing polyploidy.
jcs.biologists.org/cgi/content/full/114/16/2943
This might be the result of the interactions between parental genomes in allopolyploids (Comai et al., 2000). Another way is by favoring the onset of asexual reproduction, which is associated with polyploidy in both plants and animals. ... Another disadvantage of polyploidy includes potential changes in gene expression.
www.nature.com/scitable/topicpage/Polyploidy-1552814 www.nature.com/scitable/topicpage/Polyploidy-1552814
polyploidy in animals, as compared with plants? It is, in essence, very simple—animals .... tetraploids would still be at a reproductive disadvantage, ...
www.jstor.org/stable/2456335
Polyploidy in animals ... Polyploidy is much rarer in animals. It is found in some insects, fishes, amphibians, and reptiles. Until recently, no polyploid mammal was known. However, the 23 September 1999 issue of Nature reports that a polyploid (tetraploid;
users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Polyp... users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Polyploidy.html
Centromeric H3-like histones, which replace histone H3 in the centromeric chromatin of animals and fungi, ... Keywords: polyploid; polyploidy; disadvantage; advantage; genome; evolutionary; evolutionary potential; redundant gene; evolutionary fate; surprisingly stable; animal taxa; epigenetic; genome analyse; multiple set;
lib.bioinfo.pl/auid:16181
In addition, some polyploids have greater resistance to pests and pathogens.20 However, in all of these cases, a fitness cost exists, meaning that in many environments polyploidy is a disadvantage. ... Because whole genome duplication in animals is usually lethal, Ohno originally concluded that only two whole...
www.creationontheweb.com/content/view/5477
‘ One (PDF File)
Chromosome abnormalities, such as triploidy, are usu-ally harmful in most animals, especially higher animals. ... In addition, some polyploids have greater resistance to pests and pathogens.20 However, in all of these cases, a fitness cost exists, meaning that in many environments polyploidy is a disadvantage.
creation.com/images/pdfs/tj/j20_1/j20_1_99-104.pdf
Hybrid speciation (PDF File)
Muller’s theory24 that sex chromosomes in animals prevent sexual polyploidy owing to sex:autosome gene dosage is no longer given much credence6,21,23,25. ... 1). It helps if they can exploit a new ecological niche that is both vacant and also spatially separated to ameliorate minority cytotype disadvantage.
www.ucl.ac.uk/taxome/jim/pap/mallet07_hybspn_Nature.pdf
As with hybridization, polyploidy has commonly been viewed as an evolutionary disadvantage, typically because of problems with chromosomal pairing at meiosis leading to pollen and seed infertility (Stebbins, 1950 , 1971 ). However, Lumaret (1988) noted that natural Dactylis polyploids exhibit successful chromosome...
www.amjbot.org/cgi/content/full/91/5/707
For animals, most instances of an extra chromosome result in birth defects or even death, ... Many recent studies have examined the effects of polyploidy on meiosis. ... 18, 2009) — Extra genomes appear, on average, to offer no benefit or disadvantage to plants, but still play a key role in the origin of new species,
www.sciencedaily.com/releases/2009/09/090914172646.htm