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Since a low serum bicarbonate is potentially part of the definition of diabetic ketoacidosis, this test is not independent of the reference standard and therefore appears better than it performs in reality.
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www.eboncall.org/CATs/572.htm
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Acidemia, as measured by serum bicarbonate and/or blood pH, is common in individuals who have CRF or who are undergoing MD. Low serum bicarbonate concentrations in a MD patient almost always indicate metabolic acidosis.
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www.kidney.org/professionals/Kdoqi/guidelines_updates/n...
www.kidney.org/professionals/Kdoqi/guidelines_updates/nut_a14.html
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In general, the laboratory diagnosis of DKA is based on an elevated blood glucose (usually above 250mg/dl), a low serum bicarbonate level (usually below 15 mEq/L), and elevated anion gap, and demonstrable ketonemia.
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www.diabetesindia.com/diabetes/diabetic_ketoacidosis.ht...
www.diabetesindia.com/diabetes/diabetic_ketoacidosis.htm
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According to the letter, the rate of occurrence of persistently decreased serum bicarbonate ranged from 23% to 67% for patients treated with topiramate and 1% to 10% for placebo in clinical trial. Incidence of markedly low serum bicarbonate ranged from 3% to 11% for topiramate and 0 to less than 1% for placebo.
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www.medscape.com/viewarticle/466612
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BACKGROUND: Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain. ... RESULTS: The age-adjusted prevalence of hypoalbuminemia (serum albumin <3.8 g/dL) at a GFR of 90, 60, 30,
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www.medscape.com/medline/abstract/14871424?queryText=hy...
www.medscape.com/medline/abstract/14871424?queryText=hypoalbuminemia
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His blood glucose was high, as well as his urine glucose, urine ketones, and serum ketones. His serum bicarbonate was <12 mEq/L. His respiration was exaggerated and his breath had an acetone odor. His blood pressure was 90/60 and his pulse weak and rapid (120). ... 3. Why is the serum bicarbonate low?
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www.mhhe.com/biosci/ap/vander8e/student/olc/content/cas...
www.mhhe.com/biosci/ap/vander8e/student/olc/content/case28.mhtml
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(1), a low serum bicarbonate is found to be a simple laboratory finding that can distinguish adrenocortical-induced hyponatremia from low sodium due to syndrome of inappropriate antidiuretic hormone. The low serum bicarbonate is postulated to be due to respiratory alkalosis.
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jcem.endojournals.org/cgi/content/full/89/10/5271
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Associations between baseline (first 3 mo averaged) predialysis serum bicarbonate (HCO3–) and 2-yr mortality were examined in 56,385 MHD patients who were treated in virtually all DaVita dialysis clinics across the United States.
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cjasn.asnjournals.org/cgi/content/full/1/1/70
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Chapter 196: Serum Total Carbon Dioxide ... Low levels of total CO2 result from either metabolic acidosis or as a compensation to respiratory alkalosis. Bicarbonate levels below 10 mEq/L virtually identify metabolic acidosis as the cause, as compensation for respiratory alkalosis will not drive the bicarbonate that low.
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www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cm&part=A55...
www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cm&part=A5542
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