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And when a change in DNA sequence has no effect on protein sequence, it is a silent mutation (GCT, Ala to GCC, Ala). When a single base is added or deleted from a sequence, the codons are shifted one base, creating a totally new translation which rarely results in a functional protein. ... 5. Understand the "wobble" hypothesis.
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www.med.illinois.edu/m1/biochemistry/TA%20reviews/dnast...
www.med.illinois.edu/m1/biochemistry/TA%20reviews/dnastruc.htm
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Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG). M Coll, D Saal, C A Frederick, J Aymami, A Rich, ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC331712/
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Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG). Nucleic Acids Res. 1989 Feb 11; 17(3):911-23. ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC554705/
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DNA QUESTION 1982: L. PETERSON/AP BIOLOGY A portion of ... Additional points could be earned by stating that, in some cases, the polypeptide may not be altered, that the position of the nucleotide substituted is important ("wobble" effect) and that these changes in the code are important to natural selection and evolution.
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apbio.biosci.uga.edu/exam/Essays/html/standards/1982_dn...
apbio.biosci.uga.edu/exam/Essays/html/standards/1982_dna.html
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script.wareseeker.com/free-wobble-effect/
script.wareseeker.com/free-wobble-effect/
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The DNA hexamer crystallizes in the Z-DNA conformation at two pH values with the 5FU forming a wobble base pair with guanine In both crystal forms. No evidence of the enol or ionized form of 5FU is found under either condition.
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nar.oxfordjournals.org/cgi/content/abstract/17/3/911
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There are five bases in the genetic code because wobble introduces a new base and new pairing rules at B3. There are four ... The net effect is that triplets are assigned in such a way that merely those assignments anticipate the effect that random nucleotide context will have on information output by the genetic code.
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www.codefun.com/Genetic_role.htm
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AP BIOLOGY DNA STRUCTURE & FUNCTIO ... II. Composition of DNA ; A. "transforming factor" - discovered by Griffith, 1928 ; 1. worked with lethal and non-lethal forms of a pneumonia bacterium ... B. Molecules of deoxyribonucleic acid (DNA) discovered in the nucleus, in 1869 ; C. Chemical composition worked out in 1920's.
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www.bolthole.com/millikan/dna.htm
www.bolthole.com/millikan/dna.htm
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DNA carries out the assembly and minute to minute operation of a cell. In transcription, molecules of RNA ... The first two bases of the anticodon must pair up with the codon by the usual rules of base pairing (A with U ; G with C), but there is some latitude in the pairing of the third base (called the wobble effect).
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www.guam.net/pub/sshs/depart/science/mancuso/apbiolectu...
www.guam.net/pub/sshs/depart/science/mancuso/apbiolecture/14_translation/dnapro.htm
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