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Xanthine oxidase - Wikipedia, the free encyclopedia
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Xanthine oxidase inhibitor - Wikipedia, the free encyclopedia
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the productio...
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Keywords: autoimmune disease, inducible nitric oxide synthase, interstitial pneumonia, superantigen, xanthine oxidase ... Xanthine oxidase (XO) activity in the lung, BAL fluid, and plasma was increased with instillation of SEB, and 4-amino-6-hydroxypyrazolo(3,4-d)-pyrimidine (AHPP) significantly inhibited XO activity.
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xanthine oxidase activity Ref.5 ... "Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene."; Ichida K., Amaya Y., Noda K., Minoshima S., Hosoya T., Sakai O., Shimizu N., Nishino T.; Gene 133:279-284(1993) [PubMed: 8224915] [Abstract];
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Oster believed that the enzyme xanthine oxidase (XO) has the capacity to oxidize, or change, plasmalogen into a different substance, making it appear that the plasmalogen had disappeared. The body makes XO, but XO and plasmalogen are not normally found in the same tissue;
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Mellin et al.1 report that short- and long-term xanthine oxidase (XO) inhibition with allopurinol, initiated in rats with chronic heart failure due to myocardial infarction, improves cardiac haemodynamics and function and reverses left ventricular remodelling.
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