You are seeing Ask web results for ARGINASE.
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Arginase - Wikipedia, the free encyclopedia
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Complications of Arginase deficiency including secondary medical conditions, and symptoms, or other types of Arginase deficiency complication. ... Symptoms of Arginase deficiency...
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Causes of Arginase deficiency including triggers, underlying medical cause of Arginase deficiency, risk factors, and what causes Arginase deficiency. ... Symptoms of Arginase deficiency...
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Arginase deficiency usually becomes evident by about the age of 3. It most often appears as stiffness, especially in the legs, caused by abnormal tensing of the muscles (spasticity). ... In some affected individuals, signs and symptoms of arginase deficiency may be less severe, and may not appear until later in life...
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Overview: Arginase deficiency is thought to be the least common of the urea cycle disorders. This entity also manifests itself in a fashion somewhat different from other disorders in the group (see Physical). Two separate isozymes of ... ... The reaction normally mediated by arginase is the terminal step in the urea cycle,
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Arginase competes with iNOS for arginine, catalyzing its hydrolysis to ornithine and urea. Paper-13036070. In the IAS, ABH was found to be approximately 250 times more potent than L-HO-Arg in inhibiting the arginase activity. Paper-1978482.
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Arginase is also present in abundance in mammary glands where the urea cycle is not present: it has been suggested that the ornithine is converted to proline (Yip and Knox 1972). Farron (1973) indicates that arginases of different organs are different proteins and serve different metabolic functions.
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Arginase deficiency in untreated individuals is characterized by episodic hyperammonemia of variable degree that is infrequently severe enough to be life threatening or to cause death. Most commonly, birth and early childhood are normal.
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The Medscape Journal ... Allergy & Clinical Immunology ... Diabetes & Endocrinology...
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