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www.ncbi.nlm.nih.gov/pmc/articles/PMC371868/pdf/jcinves...
www.ncbi.nlm.nih.gov/pmc/articles/PMC371868/pdf/jcinvest00671-0180.pdf
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Factor IX clotting activity but 100% Factor IX antigenic ... Factor IX Chapel Hill ( Factor IXcH). ... variants; CRMR, CRM reduced variants; Factor IXCH, Factor. IX ...
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www.pnas.org/content/82/9/2847.full.pdf
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One ofthe CRM+ variants, factor. IX Chapel Hill, results from an amino acid substitution at one of the proteolytic activation sites, blocking cleavageand sub- ...
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www.jstor.org/stable/13993
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sociated with the light chain of factor IXachapel Hill-. Blood coagulation factor IX is a glycoprotein of Mr 57000 that participates during the middle phase of ...
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www.uniprot.org/uniprot/P00740
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Jan 25, 2012 ... >sp|P00740|FA9_HUMAN Coagulation factor IX OS=Homo sapiens GN=F9 PE= 1 .... fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position .... Natural variant, 62 – 63, 2, Missing in HEMB; severe.
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pubs.acs.org/doi/abs/10.1021/bi00348a034
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The binding constants (Kd) for normal (N), variant [Chapel Hill (CH) and Alabama (AL)], and .... full expression of factor IX, coagulant activity (Morita et al.,. 1984 ...
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www.bloodservices.ca/CentreApps/Internet/UW_V502_MainEn...
www.bloodservices.ca/CentreApps/Internet/UW_V502_MainEngine.nsf/resources/Medical_Publications/$file/Abnormal_hemostatis_in_a_knock-in_mouse_carrying.pdf
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1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC; ... mutation lysine 5 to alanine (K5A) in the Gla domain of its factor IX (FIX). The K5A ... bleeding tendency despite its in vitro clotting activity being normal.
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onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.1989.tb...
onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.1989.tb04323.x/pdf
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poorly functional factor IX variants which exhibit impaired activation. The first of these described in detail, factor IX. Chapel Hill, was shown by protein ...
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jb.oxfordjournals.org/content/105/5/756.full.pdf
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reacting material-positive variants have essentially normal levels of factor IX antigen with ... Factor IX Chapel Hill exhibits a normal ox brain prothrombin time but ...
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www.sciencedirect.com/science/article/pii/0049384879900...
www.sciencedirect.com/science/article/pii/0049384879900690
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238 FACTOR IX VARIANTS Vo1.15,No.1/2 Clotting activities. .... (12), where it was shown that Factor IX Chapel Hill only slowly could be cleaved by Factor XIa.
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