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Encyclopedia: Interleukin 6
Interleukin-6 (IL-6) is an interleukin, a pro-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading t...
en.wikipedia.org/wiki/Interleukin_6
Brief and Straightforward Guide: What is Interleukin-6?
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Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and metabolic actions. Administration of interleukin-6 results in fever, anorexia, and fatigue. Elevated levels of circulating interleukin-6...
www.annals.org/cgi/content/full/128/2/127
My Favorite Immune Protein: Interleukin-6 Interleukin-6 is especially important in the early stages of T-cell differentiation. In this phase, it reinforces the effect of IL-2 and promotes the differentiation of CD4 cells into T-helper2 cells. (Janeway et al., 2001;
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The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection.
www.ncbi.nlm.nih.gov/pubmed/12773095
Interleukin-6 (IL-6) The rationale for focussing on IL-6 as one of a key factors in etiology of AABS and neurodegeneration is based on the following evidence.
www.mcmaster.ca/inabis98/anisman/sakic0854/two.html
Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer.
www.immunityageing.com/content/4/1/1
Interleukin-6 is made mainly by some T lymphocyte. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain...
www.cancer.gov/dictionary/?CdrID=44045
A key feature in the regulation of IL-6 responses has been the identification of a soluble interleukin 6 receptor (sIL-6R), which forms a ligand–receptor complex with IL-6 that is capable of stimulating a variety of cellular responses including proliferation, differentiation and activation of inflammatory processes.
www.fasebj.org/cgi/content/full/15/1/43
The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity.
biomed.gerontologyjournals.org/cgi/content/abstract/61/... biomed.gerontologyjournals.org/cgi/content/abstract/61/6/575