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Serotonin transporter - Wikipedia, the free encyclopedia
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The serotonin transporter first binds a sodium ion, followed by serotonin, and then a chloride ion. The transporter then flips inside the cell, releasing serotonin. A potassium ion binds, and the transporter flips back out, ready to receive another serotonin molecule.
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Serotonin transporter: gene, genetic disorders, and pharmacogenetics. ... The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations.
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The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that has been associated with anxiety-related traits and susceptibility for depression.
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Serotonin signaling influences social behavior in both human and nonhuman primates. In humans, variation upstream of the promoter region of the serotonin transporter gene (5-HTTLPR) has recently been shown to influence both behavioral measures of social anxiety and amygdala response to social threats.
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Is romatic love a disorder of serotonin function? ... Alteration of the platelet serotonin transporter in romantic love by; Marazziti D, Akiskal HS, Rossi A, Cassano GB; Dipartmento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy.
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The serotonin transporter: a primary target for antidepressant drugs by; Schloss P, Williams DC; Biochemistry Department, University of Dublin, Trinity College, Ireland. schlossp@mail.tcd.ie ; J Psychopharmacol 1998; ... The serotoninergic system is known to modulate mood, emotion, sleep and appetite and thus...
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Recommended name:; Sodium-dependent serotonin transporter; Alternative name(s):; 5HT transporter; Short name=5HTT; Solute carrier family 6 member 4 ... Serotonin transporter entry ... serotonin transmembrane transporter activity...
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The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin concentrations.
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