You are seeing Ask web results for bradykinin.
 [brăd́ĭ-kī́nĭn, -kĭńĭn]
Dictionary.com · The American Heritage® Dictionary
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Bradykinin - Wikipedia, the free encyclopedia
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Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold. ... We now show that the B2 kinin receptor is expressed in rat dorsal horn neurons and that bradykinin, a B2-specific agonist, augments AMPA- and NMDA-induced, and primary afferent-evoked EPSCs, and increases the...
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Both bradykinin B2 and angiotensin II type 2 (AT2) receptors are known to stimulate renal production of nitric oxide (NO). ... We conclude that NO can be produced by 2 alternative pathways: directly through the AT2 receptor or indirectly from AT2 receptor stimulation of bradykinin via the B2 receptor.
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Bradykinin receptor - Wikipedia, the free encyclopedia
The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin. There are two Bradykinin receptors: the B 1 receptor and the B 2 recept...
en.wikipedia.org/wiki/Bradykinin_receptor |
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Vasodilation: Bradykinin is one of the most powerful known vasodilators. Its vasodilatator and hypotensive effects resulting from B2 receptor stimulation are, at least partially, the consequence of nitric oxide release.
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Bradykinin, through its B2 receptor, stimulates endothelial release of a number of vasodilators, such as nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF). ... Thus, the evidence strongly supports a role for bradykinin in mediating the cardiovascular benefits of ACE inhibitors.
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Histamine does not normally play a significant role in regulating blood flow and microvascular function. However, ... The actions of bradykinin are similar to histamine. Bradykinin is a potent stimulator of nitric oxide formation by vascular endothelium. It also stimulates prostacyclin formation.
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Local Bradykinin Formation Is Controlled by Glycosaminoglycans1 ... Bradykinin is a potent inflammatory mediator that induces vasodilation, vascular leakage, and pain sensations. This short-lived peptide hormone is liberated from its large precursor protein high molecular weight kininogen (HK) through the contact...
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