You are seeing Ask web results for editing and rearrangement because there was not a match on Dictionary.com.
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We focused on RS rearrangement as an assay for receptor editing because RS rearrangement is known to accompany extensive light chain rearrangement during ...
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Jk elements, Jk1, 2, 4, and 5 (Jk3 is a pseudogene), but even VJk5 rearrangements can be silenced by editing through rearrangements to the recombining ...
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It features print, preview, export to RTF, minimize to system tray, full text-editing features, rearrangement of nodes, full-document search, hyperlinks; on top of being slick, fast, lightweight and open source. Main features:;
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Continued antibody gene rearrangement, termed receptor editing, is an important mechanism of central B cell tolerance that may be defective in some autoimmune individuals. ... RS rearrangement levels are highest in the most highly edited B cells, and are inappropriately low in autoimmune mouse models of systemic...
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Continued antibody gene rearrangement, termed receptor editing, is an important mechanism of central B cell tolerance that may be defective in some autoimmune individuals. ... To distinguish between active and passive editing, RS rearrangement frequencies were analyzed in the 56R mouse model, where the B cell repertoire...
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B can downregulate immunoglobulin light chain gene rearrangement. Various markers of receptor editing, including recombining sequence gene rearrangements ...
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Here, the roles of IRF-4 and -8 in receptor editing were analyzed. Our results show that secondary rearrangement was impaired in IRF-4 but not IRF-8 mutant mice, suggesting that receptor editing is defective in the absence of IRF-4.
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More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow their antibodies to recognize different foreign invaders or pathogens. ... University of Pennsylvania School of Medicine ... University of Pennsylvania Health System...
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Light chain gene rearrangement in B cells, and -chain rearrangement in T cells can continue, which raises the question: how is allelic exclusion maintained, if at all, in the face of continued rearrangement? ... G. Kalmanovich and R. Mehr; Models for Antigen Receptor Gene Rearrangement. III. Heavy and Light Chain...
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A model addressing only the branching ratio and fusion efficiencies, but which allows just one rearrangement attempt per chromosome (i.e., no receptor editing), gives a : ratio of at most 2.25 (12). ... If, however, a cell does not die after such a rearrangement, it may try another rearrangement (receptor editing);
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