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acrosomal granule a large globule contained within a membrane-bounded acrosomal vesicle, which enlarges further to become the core of the acrosome of a...
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Lamellar granules are specialized epidermal organelles containing stacks of membranous disks that are extruded into the intercellular spaces in the upper...
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Typical lamellar granules were absent; instead, numerous dense cored granules (DCG) and It is suggested that the abnormal lamellar granule underlies the...
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Lamellar granules and keratohyalin granules are the intracellular cytoplasmic Lamellar granule contents are excreted into the extracellular space of the...
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Definition of lamellar granule from the online medical dictionary hosted by mondofacto.
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Conclusions The present observations indicate that VPS33B deficiency results in abnormal secretion of lamellar granules, which underlies ichthyosis in ARC syndrome. These data underscore the importance of SNARE-mediated vesicle fusion during normal epidermal differentiation.
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DELETERIOUS MUTATIONS IN VPS33B AND LAMELLAR GRANULE SECRETION IN ARC Lamellar granule secretion was found to be abnormal, as attested by the formation of the cornified cell envelope before completion of lamellar granule secretion (Figure 3A-D).
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Lamellar granules are sphingolipid-enriched organelles, probably intimately related to the tubulo-vesicular elements of the trans-Golgi network, that deliver the precursors of stratum corneum barrier lipids to the extracellular compartment. Caveolin-1 is enriched in an isolated lamellar granule fraction that is also enriched,
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Mutations in the ABCA12 gene also cause a skin disorder called lamellar ichthyosis type 2. People with this disorder have red, scaly, plate-like skin covering most of their bodies. These skin abnormalities tend to be less severe than those seen with harlequin ichthyosis.
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It was reported that truncation of CGI-58 protein results in abnormal lamellar granule (LG) formation in DCS.4 LGs have been shown to form a continuous network from the Golgi apparatus (trans-Golgi network;
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