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Ototoxicity - Wikipedia, the free encyclopedia
Ototoxicity is damage to the ear ( oto- ), specifically the cochlea or auditory nerve and sometimes the vestibular system, by a toxin. It is commonly medication-induced; ototoxic drugs include anti...
en.wikipedia.org/wiki/Ototoxicity |
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Comment: While reportedly ototoxic, these medications are rarely encountered as a source of vestibular dysfunction. Cisplatin is the most widely used anticancer drug currently and unfortunately, it is cochleotoxic. ... Metronidizole (Flagyl) has been reported on several occasions to be ototoxic (Blake and Butt 1984;
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Ototoxic drugs can cause hearing loss, both temporary and permanent. ... Ototoxic Drugs Cause Hearing Loss ... A common cause of hearing loss, especially in developing countries, is ototoxicity. An ototoxic hearing loss happens when someone takes or is given a drug that causes hearing loss as one of its side effects.
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What you should know about ototoxic medicines and damage to hearing ... As a result of using ototoxic medications, the degree of hearing loss that occurs and the amount of recovery that follows depends upon the amount and duration of the use of that particular medication.
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Ototoxicity—The Hidden Menace Part I: These ear-damaging drugs can turn your life upside down ... An ototoxic drug flipped "Ruby's" life upside down too. She explains: "I cannot drive any more. I had to quit my job as it was an hour's drive away. My mental status is now "foggy" at best. I cannot walk in the dark.
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Ototoxic drugs, which are medications that are toxic to the ear, have the potential to cause permanent or temporary hearing loss. Approximately 200 prescription and over-the-counter drugs are recognized as ototoxic.
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Any drug with the potential to cause toxic reactions to structures of the inner ear are considered ototoxic ("oto-" means ear and "toxic" means poisonous: therefore, ototoxic means poisonous to the ear).
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Comment: While reportedly ototoxic, these medications are rarely encountered as a source of vestibular dysfunction. ... Drugs that are very narrow, perhaps aimed at cell markers, would not be reasonably expected to be ototoxic. Some chemotherapy drugs are used in treatment of inner ear disease -- i.e. cytoxin,
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Ototoxic drugs include the aminoglycoside antibiotics and the antineoplastic agent cisplatin. This is a short technical report describing the dissection and culture of the adult mouse utricle. This in vitro preparation allows for detailed studies of ototoxic-drug-induced hair cell death in an adult mammalian system.
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The Medscape Journal ... Allergy & Clinical Immunology ... Diabetes & Endocrinology...
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