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Quinazoline - Wikipedia, the free encyclopedia
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Recent evidence suggests that the quinazoline-based 1-adrenoceptor antagonists, doxazosin and terazosin, exhibit a potent apoptotic effect against prostate tumor epithelial cells, whereas tamsulosin, a sulfonamide-based 1-adrenoceptor antagonist, was ineffective in inducing a similar apoptotic effect against...
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Davinder S. Theti, Vassilios Bavetsias, Lorraine A. Skelton, Jenny Titley, David Gibbs, Gerrit Jansen and Ann L. Jackman2 ... HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS ... Clinical Cancer Research...
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The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC(50) 1.8-40.0 microg/mL) and DNA topoisomerase II inhibition at a concentration of 25 microM...
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This review covers the isolation, structure determination, synthesis and biological activity of quinoline, quinazoline and acridone alkaloids from plant, microbial and animal sources. ... This review covers the isolation, structure determination, synthesis and biological activity of ... Ob/Gyn & Women's Health...
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Quinazoline is a heterocyclic double-ring structure compound containing a benzene fused to pyrimidine. There are four isomers which are identified by Nirtogen positions; Cinnoline (1,2-Benzodiazine; Benzo[c]pyridazine;
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Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky1, Richard J. Riopelle, and Gregory M. Ross ... and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada (R.J.R.) ... Received for publication January 27, 2004 ; Accepted March 26, 2004.
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Since the 1,3-diamino functions in the quinazoline ring of the lead molecule WR227825 are essential for the inhibition of DHFR, which was believed to be the mechanism of action of WR227825, compound 4 may inhibit a target other than DHFR. The identification of active metabolites of compound 4 in rats or monkeys is...
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Quinazoline-2,4(1 H ,3 H )-dione as a substitute for thymine in triple-helix forming oligonucleotides: a reassessment ... Synthesis of the quinazoline nucleosides...
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There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. ... WO/2001/021594A QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM...
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