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However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranuclear distribution pattern of unintegrated HIV-1 DNA in relation to nuclear structures as observed on the single-cell level.
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However, several studies have suggested that unintegrated viral DNA species could also support transcription. To determine the contribution of the different species of HIV-1 DNA to viral expression, we first monitored intracellular levels of various HIV-1 DNA and RNA species in a single-round infection assay.
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This unintegrated HIV DNA is in the form of both circular and linear species. Accumulation of such DNA occurs gradually during a 5 day HIV infection and is correlated with the proportion of cells involved in the production of HIV proteins.
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High levels of unintegrated forms of retroviral DNA often correlate with superinfection and accompanying cytopathic effects2–8, as, for example, in the case of feline acquired immunodeficiency7,8. In culture, HIV-1 infection also results in high levels of unintegrated viral DNA although direct correlations...
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Define Unintegrated. Search multiple spelling dictionaries online. Get definition to words. Over 100+ dictionaries. Define, Spell Check, Research, Bible names, Law Dictionary, US Cities, CIA world book, US History ... Define Unintegrated using "exact" search strategy.
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Unintegrated HIV-1 reservoir in recently infected resting CD4+ cells is highly labile. ... "This unintegrated virus provides an inducible latent reservoir because cellular activation permits integration, virus gene expression, and virus production. It remains controversial whether HIV-1 is stable in this preintegration state."
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Saenz DT, Loewen N, Leske D, Good M, Holmes J, Poeschla EM; Conference on Retroviruses and Opportunistic Infections. ... Abstr 10th Conf Retrovir Oppor Infect Feb 10 14 2003 Hynes Conv Cent Boston Mass USA Conf Retrovir Oppor Infect 10th 2003 Boston Mass. 2003 Feb 10-14; 10: abstract no. 240. ... Mayo Med Sch, Rochester, MN...
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The HIV copy number in both fractions was then determined using a quantitative PCR assay, and the percentage of unintegrated HIV DNA (HIV uDNA) was calculated. Plasma was used for 1) determination of immune complex dissociated (ICD) HIV p24 antigen (Coulter), and 2) beta 2-microglobulin (Abbott).
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Unintegrated HIV-1 proviral DNA is one of the earliest detectable forms of HIV-1, and the influence of an antiretroviral drug on its appearance may reflect the efficacy of that agent in preventing infection of new cells. ... J Med Virol. 1999 Jun;58(2):165 ... We characterized the dynamics of HIV-1 p24 (p24) antigen production,
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