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Mayo Clinic researchers working with colleagues in Germany have devised a much-needed multilevel safety feature for viruses used to treat cancer. In the process of making cancer-killing viruses more specific to cancer tumor cells, they report having improved the therapeutic effectiveness of viruses. ... Share Blog Cite...
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In this review, we consider the potential of armed therapeutic viruses, whose lytic potential is enhanced by genetically engineered therapeutic transgene expression from the virus, as potential vehicles to increase the potency of these agents. ... oncolytic virus; armed therapeutic virus; gene therapy; cancer...
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Inspiration for using cells to to deliver therapeutic polypeptide-associated nucleic acids, particularly viruses, to tumor cells arose in part from the recently reported finding that cancer cells compress intratumor vessels (40). ... We next provide a small molecule inducer of virus production and liberation.
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Safety And Effectiveness Of Therapeutic Virus That Fights Cancer Enhanced By Mayo Clinic Researchers Mayo Clinic researchers working with colleagues in Germany have devised a much-needed multilevel safety feature for viruses used to treat cancer.
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Vesicular stomatitis virus: a potential therapeutic virus for the treatment of hematologic malignancy. ... Certain strains of vesicular stomatitis virus (VSV) have been shown to be oncolytic in a wide variety of solid tumors. In the present study, we tested the leukemolytic properties of VSV using established leukemia...
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The Mayo researchers say their contribution is a key advance because it provides a method of designing a therapeutic virus that is safe, stable and that reliably targets and kills cancer cells.
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Summary: Though several antivirals have been developed and marketed to treat influenza virus infections, the development of antiviral agents with clinical activity against other respiratory viruses has been more problematic.
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Here we discuss antivirals for RVs other than influenza virus (both those available and those currently under development), considering the epidemiology of such infections, the important role played by diagnostic testing in treatment, and the hurdles that are faced in development of these compounds.
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Possible cross-reactivity with other members of the genus flavivirus mandates caution when serologic testing results are interpreted. Thus far, no therapeutic intervention has shown consistent clinical efficacy in West Nile virus disease.
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Certain strains of vesicular stomatitis virus (VSV) have been shown to be oncolytic in a wide variety of solid tumors. In the present study, we tested the leukemolytic properties of VSV using established leukemia cell lines and primary patient material.
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